Natural Wellness
The evolution of medicinal plants
Since the dawn of civilisation, nature has been humanity's main source of health and balance.
For thousands of years —from traditional Chinese medicine and Ayurveda in India to Ancient Egypt and Classical Greece— medicinal plants have been the foundation of caring for body and mind (Unschuld, 1986; Sharma & Dash, 1988; Bryan, 1930; Scarborough, 2012).
As the history of medicinal plants shows, this ancestral knowledge has been passed down from generation to generation, building a deep relationship between people and nature.
Today, that legacy is entering a new chapter.
The new generation of natural wellbeing
At Natural Wellness, we carry forward thousands of years of natural medicine, reinterpreting it to the highest standards of quality, purity and sophistication.
Our range brings together:
- Advanced natural skincare with botanical extracts
- Botanical selections derived from industrial hemp
- High-purity extracts
- Medicinal herbal teas
Each creation is a fusion of ancestral tradition and contemporary science, offering an elevated, refined and mindful wellbeing experience.
CBD, backed by the major institutions
Cannabidiol (CBD) is one of the most fascinating botanical discoveries of our time: a natural active ingredient from the hemp plant, backed by the major institutions and explored in thousands of scientific studies worldwide.
- World Health Organization · 2018The WHO concludes that CBD has an excellent safety profile and is very well tolerated: a true mark of confidence.
- United Nations · 2020The UN recognises the therapeutic value of cannabis, and pure CBD is free from any international control.
- World Anti-Doping Agency and the Olympic GamesElite athletes have been free to use CBD since 2018, including at the Tokyo 2020 and Paris 2024 Olympic Games, where Olympic athletes made it part of their recovery routines. An ally of the best athletes in the world.
- Court of Justice of the European Union · 2020European justice recognises CBD as a legal product that can be sold freely throughout the European Union.
- European Medicines Agency · 2019It approved the first CBD-based medicine across Europe, also available in Spain.
- Government of Spain · Royal Decree 903/2025Spain takes a historic step and regulates medicinal cannabis preparations in hospital pharmacies.
- European Commission · CosIngCBD is an official cosmetic ingredient in the European Union: antioxidant, protective and skin-conditioning.
57 benefits of CBD according to science
CBD is one of the most fascinating and researched natural ingredients in the world. These are 57 studies published in scientific journals, with the type of study and the full reference at the end of the page.
Women's wellbeing
- Relief on period days. In a controlled trial with 63 women, a CBD-infused tampon significantly reduced menstrual pain.Clinical trial · Milanova et al., 2023
- Less menstrual discomfort. In a study of 307 women, those who used a vaginal CBD suppository improved their symptoms more and needed fewer painkillers.Survey-based study · Dahlgren et al., 2024
- Intimate comfort. In a trial with 40 women, a topical 5% CBD gel reduced vulvar pain more than placebo.Clinical trial · Murina et al., 2025
- Endometriosis. In an animal model, CBD reduced the size of endometriosis lesions and markers of inflammation and oxidative stress.Animal study · Okten et al., 2023
- Premenstrual symptoms. In a trial with 33 women, menstrual symptoms, irritability, anxiety and stress decreased over three cycles with CBD.Clinical trial · Ferretti et al., 2024
- Menopause. In a menopause model, CBD improved bone density, glucose control and energy expenditure.Animal study · Sui et al., 2022
Skin
- Balance for oily skin. In human skin cells, CBD reduced sebum production and had a soothing effect.Laboratory study · Oláh et al., 2014
- Natural antioxidant. A scientific review describes CBD as a powerful antioxidant that protects against oxidative stress.Review · Atalay et al., 2020
- Skin antioxidant defences. In human skin cells, CBD switched on their natural antioxidant defences and boosted proteins involved in repair.Laboratory study · Casares et al., 2020
- Great potential for skin. Researchers consider it very promising for dry, sensitive or itchy skin.Review · Baswan et al., 2020
- Skin and scalp. A review of 18 studies with 1,090 people found positive results for topical cannabinoids in various skin conditions.Systematic review · Popp et al., 2023
- More hydrated atopic skin. In patients with atopic dermatitis, a CBD ointment increased hydration and reduced water loss and redness in 8 weeks.Clinical trial · Burczyk et al., 2025
- Dry, sensitive skin. With a CBD gel, dry skin improved within 2 weeks and two out of three people noticed less itching.Observational study · Maghfour et al., 2020
- Acne-prone skin. In the laboratory, CBD inhibited acne bacteria, calmed inflammation and helped regulate sebum.Laboratory study · Lee et al., 2024
- Fragile skin. In cases of very fragile skin, CBD oil applied to the skin was linked to faster healing and less discomfort.Case series · Chelliah et al., 2018
- Antibacterial action. In the laboratory, CBD killed more than 20 types of bacteria, including some resistant to antibiotics.Laboratory and animal study · Blaskovich et al., 2021
Muscles, joints and sport
- Hands and thumbs. In a trial with 18 patients, a CBD cream improved pain and hand function compared with the same cream without CBD.Clinical trial · Heineman et al., 2022
- Joints. In a survey of 428 people with arthritis, 83% noticed less pain and 66% slept better with CBD.Survey · Frane et al., 2022
- Applied to the skin over joints. In an animal model, a CBD gel applied to the skin reduced knee inflammation.Animal study · Hammell et al., 2016
- Topical CBD oil. In 29 people, a CBD oil applied to the skin reduced intense, cold and itchy sensations in the legs and feet.Clinical trial · Xu et al., 2020
- Relaxed jaw. In a trial with 60 patients, a CBD cream applied for 14 days reduced jaw pain by 70%.Clinical trial · Nitecka-Buchta et al., 2019
- Muscle recovery. In 16 athletes, CBD was linked to fewer muscle-damage markers and recovered strength at 72 hours.Clinical trial · Isenmann et al., 2021
- Ally for sport. Researchers see CBD as a great ally for muscle recovery after exercise.Review · McCartney et al., 2020
- Fibromyalgia. In a survey of 2,701 people with fibromyalgia, CBD users noticed an improvement, especially in pain.Survey · Boehnke et al., 2021
- Inflammatory response. A review brings together CBD's effects on the body's inflammatory processes.Review · Burstein, 2015
- Strong bones. In an animal study, CBD improved bone strength during healing.Animal study · Kogan et al., 2015
Calm and rest
- Better sleep quality. In an 8-week controlled trial, the CBD group enjoyed better sleep quality.Clinical trial · Kisiolek et al., 2023
- Sleeping better. In a trial with 1,793 adults, more than half of each group, including the 15 mg CBD group, slept better within 4 weeks.Clinical trial · Saleska et al., 2024
- Anxiety and rest. In 72 adults at a clinic, anxiety decreased in the first month and rest improved.Case series · Shannon et al., 2019
- Less stress. In a survey of 387 CBD users, most felt less stressed (92%) and less anxious (86%).Survey · Moltke & Hindocha, 2021
- Calm under stress. A scientific review supports CBD for different forms of anxiety.Review · Blessing et al., 2015
- Confidence when speaking in public. In a trial with 24 people, CBD reduced nervousness when speaking in public.Clinical trial · Bergamaschi et al., 2011
- Calm at key moments. In a trial with 57 people, CBD reduced anxiety during a public-speaking test.Clinical trial · Linares et al., 2019
- Calmer young people. In 37 young people, four weeks of CBD reduced their social anxiety levels compared with placebo.Clinical trial · Masataka, 2019
- Backed by 15 trials. A review of 15 clinical trials concludes that CBD can reduce anxiety.Systematic review · de Faria Coelho et al., 2024
- Emotional wellbeing. In a group of patients, 10 out of 11 reduced their post-traumatic stress symptoms after eight weeks.Case series · Elms et al., 2019
More benefits
- Digestive wellbeing. In the laboratory and in a trial with people, CBD helped protect the gut barrier against inflammation.Laboratory study and clinical trial · Couch et al., 2019
- Healthy smile. In dental plaque samples from 60 adults, cannabinoids reduced bacteria more than two commercial toothpastes.Laboratory study · Stahl & Vasudevan, 2020
Pets
- More active dogs. In a trial with 16 dogs with osteoarthritis, CBD oil was linked to less pain and more activity.Veterinary trial · Gamble et al., 2018
- Your dog's mobility. In a double-blind trial in dogs with osteoarthritis, CBD reduced pain and improved mobility.Veterinary trial · Verrico et al., 2020
- Your pet's quality of life. In 21 dogs with osteoarthritis, adding CBD to their usual care reduced pain in the first weeks.Veterinary trial · Brioschi et al., 2020
- Calm dogs at home and on the road. In a trial with 223 dogs, a single serving of CBD reduced signs of stress when left alone and when travelling by car.Veterinary trial · Hunt et al., 2023
- Happy skin for your dog. In 32 dogs with atopic dermatitis, a CBD and CBDA oil reduced itching and improved their skin.Veterinary trial · Loewinger et al., 2022
- Dogs with epilepsy. In a trial in dogs with epilepsy, 89% of those given CBD had fewer seizures.Veterinary trial · McGrath et al., 2019
- More calm days. In dogs with epilepsy, a CBD- and CBDA-rich extract reduced seizures and was very well tolerated.Veterinary trial · Garcia et al., 2022
- Long-term wellbeing. Over six months, daily CBD was very well tolerated by healthy dogs.Veterinary trial · Bradley et al., 2022
- Dogs and cats. A study with healthy dogs and cats confirmed that both tolerate CBD very well.Veterinary study · Deabold et al., 2019
- For cats too. In healthy cats, CBD oil was very well tolerated even at increasing amounts.Veterinary study · Kulpa et al., 2021
Medical research
- Epilepsy: Dravet syndrome. In a large clinical trial, CBD reduced seizures more than placebo.Clinical trial · Devinsky et al., 2017
- Epilepsy: Lennox-Gastaut syndrome. In 171 patients, seizures fell by 43.9% with CBD. This research led to the approval of Epidyolex.Clinical trial · Thiele et al., 2018
- Neuroprotection. A review examines how CBD protects nerve cells.Review · Campos et al., 2016
- Blood pressure. In healthy volunteers, CBD lowered blood pressure at rest and under stress.Clinical trial · Jadoon et al., 2017
- Impulse control. In 42 people in recovery, CBD reduced cravings and anxiety for a week.Clinical trial · Hurd et al., 2019
- Mental balance. Added to usual treatment, CBD improved symptoms in 88 patients with schizophrenia.Clinical trial · McGuire et al., 2018
- Quality of life. In patients with Parkinson's, CBD improved wellbeing and quality of life.Clinical trial · Chagas et al., 2014
Safety
- Excellent tolerability. A review of clinical data concludes that CBD has a favourable safety profile, even at high amounts.Review · Iffland & Grotenhermen, 2017
- The strongest evidence. A meta-analysis of 12 trials and 803 people confirms that CBD is well tolerated.Meta-analysis · Chesney et al., 2020
Science keeps moving forward: every year hundreds of new studies reveal the full potential of CBD. We share them so you can discover this fascinating world. Our CBD products are cosmetics for topical use, created to care for your skin and your wellbeing every day; for any health question, your healthcare professional is your best ally.
References
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- World Anti-Doping Agency (WADA). (2018). Summary of major modifications and explanatory notes – 2018 Prohibited List. Montreal.
- Tribunal de Justicia de la Unión Europea. (2020). Sentencia de 19 de noviembre de 2020, asunto C-663/18 (Kanavape).
- European Medicines Agency. (2019). Epidyolex (cannabidiol): EPAR.
- Real Decreto 903/2025, de 7 de octubre. Boletín Oficial del Estado, núm. 243, 9 de octubre de 2025 (BOE-A-2025-20077).
- European Commission. CosIng – Cosmetic Ingredients database: Cannabidiol.
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- Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2020). Antioxidative and anti-inflammatory properties of cannabidiol. Antioxidants, 9(1), 21.
- Baswan, S. M., et al. (2020). Therapeutic potential of cannabidiol (CBD) for skin health and disorders. Clinical, Cosmetic and Investigational Dermatology, 13, 927–942.
- Popp, M., et al. (2023). Cannabinoids for the treatment of hair, scalp, and skin disorders: A systematic review. Cosmetics, 10(5), 129.
- Blaskovich, M. A. T., et al. (2021). The antimicrobial potential of cannabidiol. Communications Biology, 4, 7.
- Hammell, D. C., et al. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European Journal of Pain, 20, 936–948.
- Xu, D. H., Cullen, B. D., Tang, M., & Fang, Y. (2020). The effectiveness of topical cannabidiol oil in symptomatic relief of peripheral neuropathy of the lower extremities. Current Pharmaceutical Biotechnology, 21(5), 390–402.
- Burstein, S. (2015). Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & Medicinal Chemistry, 23(7), 1377–1385.
- McCartney, D., et al. (2020). Cannabidiol and sports performance: a narrative review. Sports Medicine – Open, 6, 27.
- Kogan, N. M., et al. (2015). Cannabidiol, a major non-psychotropic cannabis constituent enhances fracture healing. Journal of Bone and Mineral Research, 30(10), 1905–1913.
- Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825–836.
- Bergamaschi, M. M., et al. (2011). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology, 36(6), 1219–1226.
- Masataka, N. (2019). Anxiolytic effects of repeated cannabidiol treatment in teenagers with social anxiety disorders. Frontiers in Psychology, 10, 2466.
- de Faria Coelho, C., et al. (2024). The impact of cannabidiol treatment on anxiety disorders: a systematic review of randomized controlled clinical trials. Life, 14(11), 1373.
- Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in anxiety and sleep: a large case series. The Permanente Journal, 23, 18-041.
- Elms, L., Shannon, S., Hughes, S., & Lewis, N. (2019). Cannabidiol in the treatment of post-traumatic stress disorder: a case series. Journal of Alternative and Complementary Medicine, 25(4), 392–397.
- Devinsky, O., et al. (2017). Trial of cannabidiol for drug-resistant seizures in the Dravet syndrome. New England Journal of Medicine, 376, 2011–2020.
- Thiele, E. A., et al. (2018). Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4). The Lancet, 391(10125), 1085–1096.
- Campos, A. C., Fogaça, M. V., Sonego, A. B., & Guimarães, F. S. (2016). Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacological Research, 112, 119–127.
- Jadoon, K. A., Tan, G. D., & O'Sullivan, S. E. (2017). A single dose of cannabidiol reduces blood pressure in healthy volunteers. JCI Insight, 2(12), e93760.
- Hurd, Y. L., et al. (2019). Cannabidiol for the reduction of cue-induced craving and anxiety in drug-abstinent individuals with heroin use disorder. American Journal of Psychiatry, 176(11), 911–922.
- McGuire, P., et al. (2018). Cannabidiol (CBD) as an adjunctive therapy in schizophrenia: a multicenter randomized controlled trial. American Journal of Psychiatry, 175(3), 225–231.
- Chagas, M. H. N., et al. (2014). Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial. Journal of Psychopharmacology, 28(11), 1088–1092.
- Iffland, K., & Grotenhermen, F. (2017). An update on safety and side effects of cannabidiol. Cannabis and Cannabinoid Research, 2(1), 139–154.
- Chesney, E., et al. (2020). Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials. Neuropsychopharmacology, 45(11), 1799–1806.
- Milanova, V., Mihaylova, K., Lazarova, I., Georgieva, T., Baxter, H., & Dobreva, D. (2023). Efficacy and usability of a cannabidiol-infused tampon for the relief of primary dysmenorrhea. Journal of Endometriosis and Uterine Disorders, 5, 100057.
- Dahlgren, M. K., Smith, R. T., Kosereisoglu, D., Sagar, K. A., Lambros, A. M., El-Abboud, C., & Gruber, S. A. (2024). A survey-based, quasi-experimental study assessing a high-cannabidiol suppository for menstrual-related pain and discomfort. npj Women's Health, 2(1).
- Murina, F., Ettore, G., Fochesato, C., Castiglione, M. G., Caruso, M., Fonti, I., & Savasi, V. (2025). Efficacy and safety of topical 5% cannabidiol plus myrcene for the treatment of vestibulodynia. Biomedicines, 13(10), 2440.
- Okten, S. B., Cetin, C., Tok, O. E., Guler, E. M., Taha, S. H., Ozcan, P., & Ficicioglu, C. (2023). Cannabidiol as a potential novel treatment for endometriosis. Reproductive BioMedicine Online, 46(5), 865–875.
- Ferretti, M. L., Stanley, T. B., Peters, E. N., Bonn-Miller, M. O., & Irons, J. G. (2024). Examination of the effects of cannabidiol on menstrual-related symptoms. Experimental and Clinical Psychopharmacology. doi:10.1037/pha0000709
- Sui, K., Tveter, K. M., Bawagan, F. G., et al. (2022). Cannabidiol-treated ovariectomized mice show improved glucose, energy, and bone metabolism. Frontiers in Pharmacology, 13, 900667.
- Kisiolek, J. N., Flores, V. A., Ramani, A., Butler, B., Haughian, J. M., & Stewart, L. K. (2023). Eight weeks of daily cannabidiol supplementation improves sleep quality and immune cell cytotoxicity. Nutrients, 15(19), 4173.
- Saleska, J. L., Bryant, C., Kolobaric, A., D'Adamo, C. R., Colwell, C. S., Loewy, D., Chen, J., & Pauli, E. K. (2024). The safety and comparative effectiveness of non-psychoactive cannabinoid formulations for the improvement of sleep. Journal of the American Nutrition Association, 43(1), 1–11.
- Burczyk, D. D., Wcisło-Dziadecka, D., Olczyk, P., Chełmecka, E., & Burczyk, W. K. (2025). Evaluation of biophysical parameters of the skin of patients with atopic dermatitis after application of an ointment containing cannabidiol and cannabigerol. Clinical, Cosmetic and Investigational Dermatology, 18, 649–662.
- Maghfour, J., Rietcheck, H. R., Rundle, C. W., et al. (2020). An observational study of the application of a topical cannabinoid gel on sensitive dry skin. Journal of Drugs in Dermatology, 19(12), 1204–1208.
- Lee, J. H., Yoon, J. Y., Kim, D. H., et al. (2024). Potential of cannabidiol as acne and acne scar treatment. Archives of Dermatological Research, 316(7), 428.
- Casares, L., García, V., Garrido-Rodríguez, M., et al. (2020). Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biology, 28, 101321.
- Chelliah, M. P., Zinn, Z., Khuu, P., & Teng, J. M. C. (2018). Self-initiated use of topical cannabidiol oil for epidermolysis bullosa. Pediatric Dermatology, 35(4), e224–e227.
- Heineman, J. T., Forster, G. L., Stephens, K. L., Cottler, P. S., Timko, M. P., & DeGeorge, B. R., Jr. (2022). A randomized controlled trial of topical cannabidiol for the treatment of thumb basal joint arthritis. The Journal of Hand Surgery, 47(7), 611–620.
- Frane, N., Stapleton, E., Iturriaga, C., Ganz, M., Rasquinha, V., & Duarte, R. (2022). Cannabidiol as a treatment for arthritis and joint pain: an exploratory cross-sectional study. Journal of Cannabis Research, 4, 47.
- Isenmann, E., Veit, S., Starke, L., Flenker, U., & Diel, P. (2021). Effects of cannabidiol supplementation on skeletal muscle regeneration after intensive resistance training. Nutrients, 13(9), 3028.
- Boehnke, K. F., Gagnier, J. J., Matallana, L., & Williams, D. A. (2021). Cannabidiol use for fibromyalgia: prevalence of use and perceptions of effectiveness in a large online survey. The Journal of Pain, 22(5), 556–566.
- Linares, I. M. P., Zuardi, A. W., Pereira, L. C. B., et al. (2019). Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Brazilian Journal of Psychiatry, 41(1), 9–14.
- Moltke, J., & Hindocha, C. (2021). Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems. Journal of Cannabis Research, 3, 5.
- Couch, D. G., Cook, H., Ortori, C., Barrett, D., Lund, J. N., & O'Sullivan, S. E. (2019). Palmitoylethanolamide and cannabidiol prevent inflammation-induced hyperpermeability of the human gut in vitro and in vivo. Inflammatory Bowel Diseases, 25(6), 1006–1018.
- Stahl, V., & Vasudevan, K. (2020). Comparison of efficacy of cannabinoids versus commercial oral care products in reducing bacterial content from dental plaque. Cureus, 12(1), e6809.
- Nitecka-Buchta, A., Nowak-Wachol, A., Wachol, K., et al. (2019). Myorelaxant effect of transdermal cannabidiol application in patients with TMD: a randomized, double-blind trial. Journal of Clinical Medicine, 8(11), 1886.
- Gamble, L.-J., Boesch, J. M., Frye, C. W., et al. (2018). Pharmacokinetics, safety, and clinical efficacy of cannabidiol treatment in osteoarthritic dogs. Frontiers in Veterinary Science, 5, 165.
- Verrico, C. D., Wesson, S., Konduri, V., et al. (2020). A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain. Pain, 161(9), 2191–2202.
- Brioschi, F. A., Di Cesare, F., Gioeni, D., et al. (2020). Oral transmucosal cannabidiol oil formulation as part of a multimodal analgesic regimen in dogs affected by spontaneous osteoarthritis. Animals, 10(9), 1505.
- Hunt, A. B. G., Flint, H. E., Logan, D. W., & King, T. (2023). A single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel. Frontiers in Veterinary Science, 10, 1112604.
- Loewinger, M., Wakshlag, J. J., Bowden, D., Peters-Kennedy, J., & Rosenberg, A. (2022). The effect of a mixed cannabidiol and cannabidiolic acid based oil on client-owned dogs with atopic dermatitis. Veterinary Dermatology, 33(4), 329–e77.
- McGrath, S., Bartner, L. R., Rao, S., Packer, R. A., & Gustafson, D. L. (2019). Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy. Journal of the American Veterinary Medical Association, 254(11), 1301–1308.
- Garcia, G. A., Kube, S., Carrera-Justiz, S., Tittle, D., & Wakshlag, J. J. (2022). Safety and efficacy of cannabidiol-cannabidiolic acid rich hemp extract in the treatment of refractory epileptic seizures in dogs. Frontiers in Veterinary Science, 9, 939966.
- Bradley, S., Young, S., Bakke, A. M., Holcombe, L., Waller, D., Hunt, A., Pinfold, K., Watson, P., & Logan, D. W. (2022). Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs. Frontiers in Veterinary Science, 9, 977457.
- Deabold, K. A., Schwark, W. S., Wolf, L., & Wakshlag, J. J. (2019). Single-dose pharmacokinetics and preliminary safety assessment with use of CBD-rich hemp nutraceutical in healthy dogs and cats. Animals, 9(10), 832.
- Kulpa, J. E., Paulionis, L. J., Eglit, G. M., & Vaughn, D. M. (2021). Safety and tolerability of escalating cannabinoid doses in healthy cats. Journal of Feline Medicine and Surgery, 23(12), 1162–1175.
